Combination chemotherapy against B 16 melanoma: bleomycin/vinblastine, bleomycin/cis-diamminedichloroplatinum, 5-fluorouracil/BCNU and 5-fluorouracil/methyl-CCNU

cover 16-5 October 2019

5 Chemotherapy

The number of melanoma cases worldwide is increasing faster than any other cancer. Although early detection, appropriate surgery, and adjuvant therapy have improved outcomes, the prognosis of metastatic melanoma remains very poor. Advanced melanoma is still associated with an extremely poor median survival, ranging from 2 to 8 months, with only 5% surviving more than 5 years and remains one of ...

Persian-translation- 16-5 October 2019

Combination chemotherapy with navelbine and continuous infusion of 5-fluorouracil in metastatic, chemotherapy refractory breast cancer.

BACKGROUND The protracted continuous infusion (PCI) of 5-fluorouracil (5-FU) has proven in several studies an active and well tolerated treatment for advanced, pretreated breast cancer. Navelbine has also activity in this setting. PATIENTS AND METHODS Heavily pretreated patients with metastatic breast carcinoma were eligible for the study. Treatment consisted of 5-FU 250 mg/m2 given as a PCI ...

Antitumor action of pyran copolymer and tilorone against Lewis lung carcinoma and B-16 melanoma.

Pyran (copolymer of divinyl ether and maleic anhydride) and tilorone [2,7-bis(2-diethylaminoethoxy) fluoren-9-one dihydrochloride] are host resistance-inducing agents that possess antitumor activity. The possible relationship of direct cytotoxicity to antitumor activity against the Lewis lung carcinoma and B-16 melanoma tumors was examined. Tilorone and tilorone congeners exhibited significant ...